The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection

SH Safiabadi Tali, JJ LeBlanc, Z Sadiq… - Clinical microbiology …, 2021 - Am Soc Microbiol
SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and …

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

P Bégin, J Callum, E Jamula, R Cook, NM Heddle… - Nature medicine, 2021 - nature.com
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear.
Although most randomized controlled trials have shown negative results, uncontrolled …

Humoral responses and serological assays in SARS-CoV-2 infections

Y Galipeau, M Greig, G Liu, M Driedger… - Frontiers in …, 2020 - frontiersin.org
In December 2019, the novel betacoronavirus Severe Acute Respiratory Disease
Coronavirus 2 (SARS-CoV-2) was first detected in Wuhan, China. SARS-CoV-2 has since …

A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

MG Joyce, HAD King, I Elakhal-Naouar… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
stresses the continued need for next-generation vaccines that confer broad protection …

A human coronavirus evolves antigenically to escape antibody immunity

RT Eguia, KHD Crawford, T Stevens-Ayers… - PLoS …, 2021 - journals.plos.org
There is intense interest in antibody immunity to coronaviruses. However, it is unknown if
coronaviruses evolve to escape such immunity, and if so, how rapidly. Here we address this …

Anti-spike protein assays to determine SARS-CoV-2 antibody levels: a head-to-head comparison of five quantitative assays

T Perkmann, N Perkmann-Nagele, T Koller… - Microbiology …, 2021 - Am Soc Microbiol
Reliable quantification of the antibody response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is highly relevant, eg, for identifying possible vaccine failure …

COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

Coronavirus Resistance Database (CoV-RDB): SARS-CoV-2 susceptibility to monoclonal antibodies, convalescent plasma, and plasma from vaccinated persons

PL Tzou, K Tao, SLK Pond, RW Shafer - Plos one, 2022 - journals.plos.org
As novel SARS-CoV-2 variants with different patterns of spike protein mutations have
emerged, the susceptibility of these variants to neutralization by antibodies has been rapidly …

Evidence of SARS-CoV-2-specific memory B cells six months after vaccination with the BNT162b2 mRNA vaccine

A Ciabattini, G Pastore, F Fiorino, J Polvere… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 mRNA vaccines have demonstrated high efficacy and immunogenicity, but
limited information is currently available on memory B cell generation and long-term …