Intranasal drug delivery: opportunities and toxicologic challenges during drug development
LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …
increased. This review article summarises information on intranasal administration for local …
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
[HTML][HTML] Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease
like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid …
like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid …
The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …
neuronal dysfunctionality which results in disability and human life-threatening events. In …
Application of chitosan modified nanocarriers in breast cancer
As per the WHO, every year around 2.1 million women are detected with breast cancer. It is
one of the most invasive cancer in women and second most among all, contributing around …
one of the most invasive cancer in women and second most among all, contributing around …
Biomaterials in treatment of Alzheimer's disease
Alzheimer's disease (AD) is a non-recoverable progressive neurodegenerative disorder
most prevalent but not limited to the old age population. After all the scientific efforts, there …
most prevalent but not limited to the old age population. After all the scientific efforts, there …
Recent advances in Bio-conjugated nanocarriers for crossing the Blood-Brain Barrier in (pre-) clinical studies with an emphasis on vesicles
A Poustforoosh, MH Nematollahi… - Journal of Controlled …, 2022 - Elsevier
The brain is one of the most challenging organs for drug delivery. It is preserved by the
blood-brain barrier (BBB), which controls the transport of components into and out of the …
blood-brain barrier (BBB), which controls the transport of components into and out of the …
Intranasal drug administration in Alzheimer-type dementia: Towards clinical applications
R Taléns-Visconti, JV de Julián-Ortiz, O Vila-Busó… - Pharmaceutics, 2023 - mdpi.com
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …
Advances in designing of polymeric micelles for biomedical application in brain related diseases
In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …