Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

Determining the chemical composition of biological materials is paramount to the study of
natural phenomena. Here, we describe the composition of model gram-negative outer …

Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …

Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action
has been used by animals for millions of years, fulfill many requirements of the …

Introduction: With the increase in multi-drug resistant P. aeruginosa, antimicrobials with a
novel mechanism of action are needed that can target these infections. Areas covered …

The outbreak of antimicrobial resistance, together with the lack of newly developed
antimicrobial drugs, represents an alarming signal for both human and animal healthcare …

Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to developing new antibiotics to combat ARB, sensitizing …

With the increasing resistance of many Gram-negative bacteria to existing classes of
antibiotics, identifying new paradigms in antimicrobial discovery is an important research …

The outer membrane of gram-negative bacteria is a permeability barrier that prevents the
efficient uptake of molecules with large scaffolds. As a consequence, a number of antibiotic …

Bacterial lipoproteins are a subset of membrane proteins localized on either leaflet of the
lipid bilayer. These proteins are anchored to membranes through their N-terminal lipid …