Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

CR Clapier, J Iwasa, BR Cairns… - Nature reviews Molecular …, 2017 - nature.com
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Energy-driven genome regulation by ATP-dependent chromatin remodellers

S Eustermann, AB Patel, KP Hopfner, Y He… - … Reviews Molecular Cell …, 2024 - nature.com
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Structure and function of chromatin remodelers

AA Reyes, RD Marcum, Y He - Journal of molecular biology, 2021 - Elsevier
Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …

Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1

A Osakabe, Y Takizawa, N Horikoshi… - Nature …, 2024 - nature.com
The histone H2A variant H2A. W occupies transposons and thus prevents access to them in
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease

A Alendar, A Berns - Genes & Development, 2021 - genesdev.cshlp.org
Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

Expansion of the ISWI chromatin remodeler family with new active complexes

M Oppikofer, T Bai, Y Gan, B Haley, P Liu… - EMBO …, 2017 - embopress.org
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes
isolated to date pair one of six regulatory subunits with one of two highly similar ATP ases …

A novel histone H4 variant H4G regulates rDNA transcription in breast cancer

M Long, X Sun, W Shi, A Yanru… - Nucleic Acids …, 2019 - academic.oup.com
Histone variants, present in various cell types and tissues, are known to exhibit different
functions. For example, histone H3. 3 and H2A. Z are both involved in gene expression …

[HTML][HTML] INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling

O Willhoft, DB Wigley - Current Opinion in Structural Biology, 2020 - Elsevier
The INO80 family of chromatin remodellers are multisubunit complexes that perform a
variety of tasks on nucleosomes. Family members are built around a heterohexamer of RuvB …

A poly-ADP-ribose trigger releases the auto-inhibition of a chromatin remodeling oncogene

HR Singh, AP Nardozza, IR Möller, G Knobloch… - Molecular cell, 2017 - cell.com
DNA damage triggers chromatin remodeling by mechanisms that are poorly understood.
The oncogene and chromatin remodeler ALC1/CHD1L massively decompacts chromatin in …

Structural rearrangements of the histone octamer translocate DNA

S Bilokapic, M Strauss, M Halic - Nature communications, 2018 - nature.com
Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic
genomes. Nucleosomes are highly dynamic and are remodeled with the help of ATP …