Trends in kinase drug discovery: targets, indications and inhibitor design

MM Attwood, D Fabbro, AV Sokolov, S Knapp… - Nature Reviews Drug …, 2021 - nature.com
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Detection and characterization of lung cancer using cell-free DNA fragmentomes

D Mathios, JS Johansen, S Cristiano, JE Medina… - Nature …, 2021 - nature.com
Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for
cancer detection and intervention. Here, we use a machine learning model for detecting …

Cancer progress and priorities: lung cancer

MB Schabath, ML Cote - Cancer epidemiology, biomarkers & prevention, 2019 - AACR
In the United States, lung cancer is the second most common diagnosed cancer and the
leading cause of cancer-related death. Although tobacco smoking is the major risk factor …

[HTML][HTML] The impact of pre-and post-image processing techniques on deep learning frameworks: A comprehensive review for digital pathology image analysis

M Salvi, UR Acharya, F Molinari… - Computers in Biology and …, 2021 - Elsevier
Recently, deep learning frameworks have rapidly become the main methodology for
analyzing medical images. Due to their powerful learning ability and advantages in dealing …

Lung cancer risk prediction with machine learning models

E Dritsas, M Trigka - Big Data and Cognitive Computing, 2022 - mdpi.com
The lungs are the center of breath control and ensure that every cell in the body receives
oxygen. At the same time, they filter the air to prevent the entry of useless substances and …

Mapping of global, regional and national incidence, mortality and mortality-to-incidence ratio of lung cancer in 2020 and 2050

R Sharma - International Journal of Clinical Oncology, 2022 - Springer
Aim Lung cancer is the leading cause of cancer deaths worldwide. This study examines the
current and future burden of lung cancer at global, regional, and national levels. Methods …

Artificial intelligence in lung cancer pathology image analysis

S Wang, DM Yang, R Rong, X Zhan, J Fujimoto, H Liu… - Cancers, 2019 - mdpi.com
Objective: Accurate diagnosis and prognosis are essential in lung cancer treatment
selection and planning. With the rapid advance of medical imaging technology, whole slide …

Current understanding of the intratumoral microbiome in various tumors

C Xue, Q Chu, Q Zheng, X Yuan, Y Su, Z Bao, J Lu… - Cell Reports …, 2023 - cell.com
It is estimated that in the future, the number of new cancer cases worldwide will exceed the
19.3 million recorded in 2020, and the number of deaths will exceed 10 million. Cancer …

Lung cancer in never smokers: The role of different risk factors other than tobacco smoking

L Corrales, R Rosell, AF Cardona, C Martin… - Critical reviews in …, 2020 - Elsevier
Lung cancer (LC), the leading cause of cancer-related deaths worldwide, is a complex and
highly heterogeneous disease. Additional to its biological complexity, LC patients are often …