Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Advances in islet encapsulation technologies
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes
AL Burrack, T Martinov, BT Fife - Frontiers in endocrinology, 2017 - frontiersin.org
Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …
immune system. Despite improvements in insulin analogs and continuous blood glucose …
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for
maintenance immunosuppression. We report a strategy through which cotransplantation of …
maintenance immunosuppression. We report a strategy through which cotransplantation of …
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic
immunosuppression to control rejection of allogeneic islets induces morbidities and impairs …
immunosuppression to control rejection of allogeneic islets induces morbidities and impairs …
Engineering immunomodulatory biomaterials for type 1 diabetes
CL Stabler, Y Li, JM Stewart… - Nature Reviews Materials, 2019 - nature.com
A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …
Rapid on-demand extracellular vesicle augmentation with versatile oligonucleotide tethers
Exosomes show potential as ideal vehicles for drug delivery because of their natural role in
transferring biological cargo between cells. However, current methods to engineer …
transferring biological cargo between cells. However, current methods to engineer …
[HTML][HTML] Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond
S Abbaszadeh, V Nosrati-Siahmazgi, K Musaie… - Advanced Drug Delivery …, 2023 - Elsevier
Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …
of impaired tissues or organs. While current technologies can enhance the survival of …
Local Immunomodulatory Strategies to Prevent Allo‐Rejection in Transplantation of Insulin‐Producing Cells
Islet transplantation has shown promise as a curative therapy for type 1 diabetes (T1D).
However, the side effects of systemic immunosuppression and limited long‐term viability of …
However, the side effects of systemic immunosuppression and limited long‐term viability of …
Nanotechnology in cell replacement therapies for type 1 diabetes
Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …