Fetal nigral grafts have been demonstrated to survive, secrete dopamine, form synaptic
connections with host neurons, and reverse behavioral disturbances in experimental models …

This paper provides an overview of the compensatory mechanisms which come into action
during experimental and human parkinsonism. The intrinsic properties of the dopaminergic …

Brain-derived neurotrophic factor (BDNF) has potent effects on survival and morphology of
dopaminergic neurons and thus its loss could contribute to death of these cells in …

Nigrostriatal dopaminergic neurons undergo sprouting around the margins of a striatal
wound. The mechanism of this periwound sprouting has been unclear. In this study, we have …

We performed fetal nigral transplantations in 4 Parkinson's disease (PD) patients. Solid
grafts were bilaterally implanted into the postcommissural putamen using 3 to 4 donors per …

A patient with Parkinson's disease received bilateral fetal human nigral implants from six
donors aged 6.5 to 9 weeks post‐conception. Eighteen months following a post‐operative …

Recent work, largely carried out in primate models of Parkinson's disease (PD), indicates
that residual dopaminergic neurons in the midbrain and their axons to the nucleus …

Following injury to the mammalian CNS, axons sprout in the vicinity of the wound margin.
Growth then ceases and axons fail to cross the lesion site. In this study, using dopaminergic …

• Experimental studies in rodents show that β-nerve growth factor can increase the survival,
neurite outgrowth, and functional effect of grafts of adrenal chromaffin cells to the basal …

Dopaminergic lesions result in the acute loss of striatal dopamine content, the loss of
tyrosine hydroxylase-immunoreactive fibers, upregulation of preproenkephalin mRNA …