The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases

Y Pan, T Matsunaga, T Zhang, T Akaike - Biomolecules, 2025 - mdpi.com
Oxidation-reduction (redox) reactions are fundamental to sustaining life, with reactive
oxygen and nitrogen species playing pivotal roles in cellular signaling and homeostasis …

Supersulfides suppress type-Ⅰ and type-Ⅱ interferon responses by blocking JAK/STAT signaling in macrophages

X Li, T Toyomoto, T Zhang, C Guo… - International …, 2024 - academic.oup.com
Interferons (IFNs) are cytokines produced and secreted by immune cells when viruses,
tumor cells, and so forth, invade the body. Their biological effects are diverse, including …

Understanding Polysulfide-Mediated Papain Inhibition and Differentiating between Disulfide vs Persulfide Formation

M Shieh, AY Chung, S Lindahl, M Veliz… - ACS Chemical …, 2024 - ACS Publications
Protein cysteine residues are sensitive to redox-regulating molecules, including reactive
sulfur species (RSS). As an important member of the RSS family, polysulfides are known to …