Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Microglia are the resident immune cells of the central nervous system, undertaking
surveillance role and reacting to brain homeostasis and neurological diseases. Recent …

Hypericin is widely utilized for its precise antidepressant properties, but its exact
antidepressant mechanism remains unclear. Gap junctions, which were predominantly …

The gap-junction-coupled astroglial network plays a central role in the regulation of
neuronal activity and synchronisation, but its involvement in the pathogenesis of neuronal …

The pharmacological treatment of epilepsy is purely symptomatic. Despite many decades of
intensive research, causal treatment of this common neurologic disorder is still unavailable …

Background Without a viable cure, chronic kidney disease is a global health concern.
Inflammatory damage in and around the renal tubules dictates disease severity and is …

Over the past decade, boldine, a naturally occurring alkaloid found in several plant species
including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of …

Depression is a common mood disorder characterized by a range of clinical symptoms,
including prolonged low mood and diminished interest. Although many clinical and animal …

Background Accompanied by activation of the NOD-like receptor protein 3 (NLRP3)
inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated …