Hallmarks of senescence and aging
Sažetak The complex process of biological aging, as an intrinsic feature of living beings, is
the result of genetic and, to a greater extent, environmental factors and time. For many of the …
the result of genetic and, to a greater extent, environmental factors and time. For many of the …
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic …
SN Baskoylu, J Yersak, P O'Hern, S Grosser… - PLoS …, 2018 - journals.plos.org
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis
(ALS), a neurodegenerative disease that disproportionately affects glutamatergic and …
(ALS), a neurodegenerative disease that disproportionately affects glutamatergic and …
Substitution of sugar-sweetened beverages for other beverages: can it be the next step towards healthy aging?
Abstract Purpose of Review With the prolongation of life expectancy, the gap between
lifespan and “health span,” the disease-free lifespan, has been widening due to the massive …
lifespan and “health span,” the disease-free lifespan, has been widening due to the massive …
[HTML][HTML] Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence
Retinal pigment epithelium (RPE) performs numerous functions critical to retinal health and
visual function. RPE senescence is a hallmark of aging and degenerative retinal disease …
visual function. RPE senescence is a hallmark of aging and degenerative retinal disease …
[HTML][HTML] NLRP3 inflammasome activation contributes to the pathogenesis of cardiocytes aging
LZ Liao, ZC Chen, SS Wang, WB Liu, CL Zhao… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Objective: The NOD-like receptor protein 3 (NOD-like receptor protein 3, NLRP3)
inflammasome is associated with many physiological processes related to aging. We …
inflammasome is associated with many physiological processes related to aging. We …
[HTML][HTML] Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion
H Sugihara, N Teramoto, K Yamanouchi… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Sarcopenia is the age-related loss of skeletal muscle mass and function. Skeletal muscle
comprises diverse progenitor cells, including mesenchymal progenitor cells (MPCs), which …
comprises diverse progenitor cells, including mesenchymal progenitor cells (MPCs), which …
[HTML][HTML] Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative …
B Chhunchha, E Kubo, P Singh, DP Singh - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
Progressive deterioration of antioxidant response in aging is a major culprit in the initiation
of age-related pathobiology induced by oxidative stress. We previously reported that …
of age-related pathobiology induced by oxidative stress. We previously reported that …
Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail
Environmental oxidative stress threatens cellular integrity and should therefore be avoided
by living organisms. Yet, relatively little is known about environmental oxidative stress …
by living organisms. Yet, relatively little is known about environmental oxidative stress …
Anti-aging activity, in silico modeling and molecular docking from Sonneratia Caseolaris
BACKGROUND: Anti-aging agents contribute to the prevention and control of skin
photoaging. Antioxidant containing cosmetic has anti-aging therapy that can inhibit free …
photoaging. Antioxidant containing cosmetic has anti-aging therapy that can inhibit free …
Raman and infrared spectroscopy reveal that proliferating and quiescent human fibroblast cells age by biochemically similar but not identical processes
K Eberhardt, C Matthäus, S Marthandan, S Diekmann… - PLoS …, 2018 - journals.plos.org
Dermal fibroblast cells can adopt different cell states such as proliferation, quiescence,
apoptosis or senescence, in order to ensure tissue homeostasis. Proliferating (dividing) cells …
apoptosis or senescence, in order to ensure tissue homeostasis. Proliferating (dividing) cells …