Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Cell migration is a highly integrated multistep process that orchestrates embryonic
morphogenesis; contributes to tissue repair and regeneration; and drives disease …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Environment-mediated drug resistance is a form of de novo drug resistance that protects
tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease …

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients
die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments …

The ability of cells to regulate dynamically their adhesion to one another and to the
extracellular matrix (ECM) that surrounds them is essential in multicellular organisms. The …

Semaphorins are secreted or transmembrane proteins that regulate cell motility and
attachment in axon guidance, vascular growth, immune cell regulation and tumour …