• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Abstract Abstract The European Society of Cardiology 2021 guideline on cardiovascular
(CV) disease (CVD) prevention in clinical practice has major implications for both CV risk …

Cardiovascular diseases remain the number one cause of death globally. Cardiovascular
disease risk scores are an integral tool in primary prevention, being used to identify …

Background The kidney failure risk equation (KFRE) uses age, sex, GFR, and urine albumin-
to-creatinine ratio (ACR) to predict kidney failure risk in people with GFR< 60 ml/min per …

Rationale & Objective Sex differences in cardiovascular disease (CVD) are well established,
but whether chronic kidney disease (CKD) modifies these risk differences and whether they …

Background Chronic kidney disease (CKD) is often detected late, leading to substantial
health loss and high treatment costs. Screening the general population for albuminuria …

Based on a wealth of evidence, aspirin is one of the cornerstones of secondary prevention of
cardiovascular disease. However, despite several studies showing efficacy also in primary …

Abstract Aims The European Systematic Coronary Risk Evaluation 2 (SCORE2) and
SCORE2-Older Persons (OP) models are recommended to identify individuals at high 10 …

Albuminuria, an established biomarker of the progression of chronic kidney disease, is also
recognized as a biomarker for the risk of cardiovascular disease. Elevated urinary albumin …

Introduction Type 2 diabetes mellitus (T2DM) is a leading cause of chronic kidney disease
(CKD) globally. Both conditions substantially worsen patients' prognosis. Current data on …