Computational enzyme design has been successfully applied to identify new alternatives to
natural enzymes for the biosynthesis of important compounds. However, the moderate …

Unnatural amino acids (UAAs) offer significant promise in a wide range of applications,
including drug discovery, the custom design of peptides and proteins, and their utility and …

Glutamate dehydrogenases (GDH) serve as the key regulated enzyme that links protein and
carbohydrate metabolism. Combined with motif reassembly and mutation, novel GDHs were …

NADPH-dependent amino acid dehydrogenases (AADHs) are favorable enzymes to
construct artificial biosynthetic pathways in whole-cell for high-value noncanonical amino …

To design D‐amino acid dehydrogenase (DAADH) for enhanced stability, the interactions of
the subunit interfaces of DAADH were analyzed. Interaction network analysis of DAADH …