Organismal aging is inherently connected to the aging of its constituent cells and systems.
Reducing the biological age of the organism may be assisted by reducing the age of its cells …

Cell state transitions are prevalent in biology, playing a fundamental role in development,
homeostasis and repair. Dysregulation of cell state transitions can lead to or occur in a wide …

The discovery of mouse embryonic stem cells in 1981 transformed research in mammalian
developmental biology and functional genomics. The subsequent generation of human …

Naïve pluripotency is sustained by a self-reinforcing gene regulatory network (GRN)
comprising core and naïve pluripotency-specific transcription factors (TFs). Upon exiting …

Introduction Cell fate determination and transition are of paramount importance in biology
and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells …

Embryonic stem cells (ESCs) are defined as stem cells with self-renewing and differentiation
capabilities. These unique properties are tightly regulated and controlled by complex …

Somatic cell nuclear transfer (SCNT) can reprogram differentiated somatic cells into
totipotency. Although pre-implantation development of SCNT embryos has greatly improved …

Abstract Induced Pluripotent Stem Cells (iPSCs) are nowadays a common starting point for
wide-ranging applications including 3D disease modeling (ie organoids) and in future …

Bone morphogenic protein (BMP) signaling plays an essential and highly conserved role in
embryo axial patterning in animal species. However, in mammalian embryos, which develop …

Development is characterized by consecutive cell state transitions that build on each other
and ultimately lead to the generation of the numerous different cell types found in the …