Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …

The persistence of undetectable disseminated tumour cells (DTCs) after primary tumour
resection poses a major challenge to effective cancer treatment,–. These enduring dormant …

Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …

CRISPR-Cas systems recognize foreign genetic material using CRISPR RNAs (crRNAs). In
type II systems, a trans-activating crRNA (tracrRNA) hybridizes to crRNAs to drive their …

Bacterial transcriptional networks consist of hundreds of transcription factors and thousands
of promoters. However, the true complexity of transcription in a bacterial pathogen and the …

The transcriptome is a powerful proxy for the physiological state of a cell, healthy or
diseased. As a result, transcriptome analysis has become a key tool in understanding the …

The emergence of next-generation sequencing platforms led to resurgence of research in
whole-genome shotgun assembly algorithms and software. DNA sequencing data from the …

Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …

Rapidly evolving sequencing technologies produce data on an unparalleled scale. A central
challenge to the analysis of this data is sequence alignment, whereby sequence reads must …