Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Organs-on-a-chip have emerged as next-generation tissue engineered models to accurately
capture realistic human tissue behaviour, thereby addressing many of the challenges …

During metastasis, all cancer types must migrate through crowded multicellular
environments. Simultaneously, cancers appear to change their biophysical properties …

YAP is a key mechanotransduction protein with essential roles in diverse physiological
processes. Dysregulation in YAP activity is associated with multiple diseases such as …

Cellular traction forces influence epithelial behavior, including wound healing and cell
extrusion. Here, we describe a simple in vitro traction force microscopy (TFM) protocol using …

The sensing and generation of cellular forces are essential aspects of life. Traction force
microscopy (TFM) has emerged as a standard broadly applicable methodology to measure …

Collective cell migration is not only important for development and tissue homeostasis but
can also promote cancer metastasis. To migrate collectively, cells need to coordinate …

Epithelial to Mesenchymal Transition (EMT) is a dynamic, morphogenetic process
characterized by a phenotypic shift in epithelial cells towards a motile and often invasive …

Planar biaxial testing offers a physiologically relevant approach for mechanically
characterizing thin deformable soft tissues, but often relies on erroneous assumptions of …