The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major
problem in our super-aging society. Bone regeneration is one of the main topics of concern …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Cell–cell fusion remains the least understood type of membrane fusion process. However,
the last few years have brought about major advances in understanding fusion between …

Osteoclasts (OCLs) are hematopoietic cells whose physiological function is to degrade
bone. OCLs are key players in the processes that determine and maintain the mass, shape …

Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for
bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone …

Aim In this article, the interplay between bone resorbing and bone forming cells is reviewed.
Method This review examines the comprehensive literature on the interaction between bone …

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …

Introduction Osteoporosis is the most common bone disorder where the hyperactive
osteoclasts represent the leading role during the pathogenesis. Targeting hyperactive …

Simple Summary The formation of multinucleated cells is critical for mature osteoclast
generation. For this to happen, mononuclear pre-osteoclasts migrate in proximity to other …

Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …