Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Polycyclic cage scaffolds have been successfully used in the development of numerous lead
compounds demonstrating activity in the central nervous system (CNS). Several …

Background: The human Monoamine Transporters (hMATs), primarily including hSERT,
hNET and hDAT, are important targets for the treatment of depression and other behavioral …

This account deals with our work on cage systems that was reported during the past two
decades. Here, we summarized various new synthetic routes to diverse cage polycycles by …

A new synthetic route to D 3-trishomocubanone and oxa-D 3-trishomocubane derivatives
has been established by the rearrangement approach. A remotely located methyl substituent …

A series of racemic N-arylalkyl-2-azaadamantan-1-ols (9–15) and the corresponding
deoxygenated, achiral N-arylalkyl-2-azaadamantanes (23–29) were synthesized and …

Several libraries of similarly N-substituted 8-aminopentacyclo [5.4. 0.0 2, 6. 0 3, 10. 0 5, 9]
undecanes (9), N-methyl-8-aminopentacyclo [5.4. 0.0 2, 6. 0 3, 10. 0 5, 9] undecanes (14) …

Several functionalized cage propellanes and D 3-trishomocubanes containing spiro linkage
have been reported starting with commercially available materials such as 1, 4 …

A library of N-substituted 4-azahexacyclo [5.4. 1.02, 6.03, 10.05, 9.08, 11] dodecan-3-ols
(AHDs) was synthesized and subjected to competition binding assays at σ1 and σ2 …

In this study, a pentacyclic keto-olefin was treated with thallium (III) nitrate trihydrate,
resulting in the formation of mono ring-expanded product. However, when the …