Autophagy, a conserved catabolic process, plays an immensely significant role in a variety
of diseases. However, whether it imparts a protective function in diseases remains …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies
in PD patients show evidence of augmented levels of potent pro-inflammatory molecules eg …

Parkinson's disease is a progressive neurodegenerative disorder characterized by the
degeneration of midbrain nigral dopaminergic neurons. Although its etiology remains …

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor
symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated …

The last decade has experienced the emergence of microRNAs as a key molecular tool for
the diagnosis and prognosis of human diseases. Although the focus has mostly been on …

Parkinson's disease is a slowly progressive neurodegenerative disease characterised by
dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the …

The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a
consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads …