Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of
PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro …

Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining
cellular health. In this process, a double membrane structure termed an autophagosome …

Ammonia is thought to be a cytotoxin and its increase in the blood impairs cell function.
However, whether and how this toxin triggers cell death under pathophysiological conditions …

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …

The cystine-glutamate antiporter, xCT, supports a glutathione synthesis program enabling
cancer cells to cope with metabolically stressful microenvironments. Up-regulated xCT, in …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …