Methylene blue and its analogues as antidepressant compounds

A Delport, BH Harvey, A Petzer, JP Petzer - Metabolic brain disease, 2017 - Springer
Methylene Blue (MB) is considered to have diverse medical applications and is a well-
described treatment for methemoglobinemias and ifosfamide-induced encephalopathy. In …

Indanones as high‐potency reversible inhibitors of monoamine oxidase

S Mostert, A Petzer, JP Petzer - ChemMedChem, 2015 - Wiley Online Library
Recent reports document that α‐tetralone (3, 4‐dihydro‐2H‐naphthalen‐1‐one) is an
appropriate scaffold for the design of high‐potency monoamine oxidase (MAO) inhibitors …

Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework

A Shetnev, A Osipyan, S Baykov, A Sapegin… - Bioorganic & Medicinal …, 2019 - Elsevier
Abstract Series of structurally diverse 2-imidazoline derivatives have been synthesized by
condensation of substituted aldehydes with ethylenediamine, Pd-catalyzed N-arylation of 2 …

Monoamine oxidase inhibitory activities of heterocyclic chalcones

C Minders, JP Petzer, A Petzer, ACU Lourens - Bioorganic & Medicinal …, 2015 - Elsevier
Studies have shown that natural and synthetic chalcones (1, 3-diphenyl-2-propen-1-ones)
possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the …

New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

C De Monte, S Carradori, P Chimenti, D Secci… - European journal of …, 2014 - Elsevier
Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and
antidepressant activities of the components of Crocus sativus L., their effects on the human …

New 2-pyrazoline and hydrazone derivatives as potent and selective monoamine oxidase A inhibitors

U Salgin-Goksen, G Telli, A Erikci… - Journal of medicinal …, 2021 - ACS Publications
Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3, 5-
disubstitutedphenyl-2-pyrazoline structure and nine compounds having N′-(1, 3 …

α-Tetralone derivatives as inhibitors of monoamine oxidase

LJ Legoabe, A Petzer, JP Petzer - Bioorganic & medicinal chemistry letters, 2014 - Elsevier
In the present study, a series of fifteen α-tetralone (3, 4-dihydro-2H-naphthalen-1-one)
derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine …

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase

MS Nel, A Petzer, JP Petzer, LJ Legoabe - Bioorganic & Medicinal …, 2016 - Elsevier
In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were
synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) …

[HTML][HTML] Monoamine oxidase inhibition by kavalactones from kava (piper methysticum)

D Prinsloo, S Van Dyk, A Petzer, JP Petzer - Planta medica, 2019 - thieme-connect.com
Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary
amines and are targets for the treatment of neuropsychiatric and neurodegenerative …

2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase

MS Nel, A Petzer, JP Petzer, LJ Legoabe - Bioorganic chemistry, 2016 - Elsevier
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were
synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) …