This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies
using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis …

Clinical acute pancreatitis (AP) is marked by an early phase of systemic inflammatory
response syndrome (SIRS) with multiorgan dysfunction (MODS), and a late phase …

Signal transduction by the ryanodine receptor (RyR) is essential in many excitable cells
including all striated contractile cells and some types of neurons. While its transmembrane …

Acute pancreatitis (AP) is one of the most common gastroenterological disorders leading to
hospitalization. It has long been debated whether biliary AP, about 30% to 50% of all cases …

Ryanodine receptors (RyRs) are large conductance intracellular channels controlling
intracellular calcium homeostasis in myocytes, neurons, and other cell types. Loss of RyR's …

Mutations in RYR1 encoding the ryanodine receptor (RyR) skeletal muscle isoform (RyR1)
are a common cause of inherited neuromuscular disorders. Despite its expression in a wide …

Pancreatitis is a condition that causes inflammation in the pancreas, an organ located
behind the stomach. This condition often presents as neuropathic, inflammatory, and/or …