WDR5 is a conserved nuclear protein that scaffolds the assembly of epigenetic regulatory
complexes and moonlights in functions ranging from recruiting MYC oncoproteins to …

Abstract KMT2C and KMT2D are histone lysine methyltransferases responsible for the
monomethylation of histone 3 lysine 4 (H3K4) residues at gene enhancer sites. KMT2C/D …

As a core chromatin-regulatory scaffolding protein, WDR5 mediates numerous protein–
protein interactions (PPIs) with other partner oncoproteins. However, small-molecule …

Neutrophil extracellular traps (NETs) have been implicated in many cancers, but the
regulatory mechanisms in the context of breast cancer have not been thoroughly discussed …

The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for
cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein …

The last few years have seen an increasing number of discoveries which collectively
demonstrate that histone and DNA modifying enzyme modulate different stages of …

Abstract WD repeat domain 5 (WDR5) is a prominent target for pharmacological inhibition in
cancer through its scaffolding role with various oncogenic partners such as MLL and MYC …

Background Cholangiocarcinoma (CCA) is a highly malignant, rapidly progressing tumor of
the bile duct. Owing to its chemoresistance, it always has an extremely poor prognosis …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
with a poor prognosis and limited options for targeted therapies. Identifying new molecular …

Histones play crucial roles in both promoting and repressing gene expression, primarily
regulated through post-translational modifications (PTMs) at specific amino acid residues …