Abstract KEOPS (K inase, E ndopeptidase and O ther P roteins of S mall size) is a five-
subunit protein complex that is highly conserved in eukaryotes and archaea and is essential …

The universal N 6-threonylcarbamoyladenosine (t6A) modification occurs at position 37 of
tRNAs that decipher codons starting with adenosine. Mechanistically, t6A stabilizes …

Galloway–Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by
the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain …

Background The study of the conservation of gene order or synteny constitutes a powerful
methodology to assess the orthology of genomic regions and to predict functional …

The highly conserved Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/
Endopeptidase‐like and Kinase associated to transcribed Chromatin (EKC) protein complex …

The ancient UbiB protein kinase-like family is involved in isoprenoid lipid biosynthesis and is
implicated in human diseases, but demonstration of UbiB kinase activity has remained …

N6-threonyl-carbamoylation of adenosine 37 of ANN-type tRNAs (t6A) is a universal
modification essential for translational accuracy and efficiency. The t6A pathway uses two …

Cerebral cavernous malformations (CCMs) are alterations in brain capillary architecture that
can result in neurological deficits, seizures, or stroke. We recently demonstrated that CCM3 …

RNase L is an ankyrin repeat domain-containing dual endoribonuclease-pseudokinase that
is activated by unusual 2,′ 5′-oligoadenylate (2-5A) second messengers and which …

The YgjD/Kae1 family (COG0533) has been on the top‐10 list of universally conserved
proteins of unknown function for over 5 years. It has been linked to DNA maintenance in …