The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

The process of protein ubiquitination and deubiquitination plays an important role in
maintaining protein stability and regulating signal pathways, and protein homeostasis …

Nuclear factor erythroid-2–related factor 1 (NRF1) and NRF2 are essential for maintaining
redox homeostasis and coordinating cellular stress responses. They are highly homologous …

Transcription factor Nrf1 acts as a unique vital player in maintaining cellular homeostasis
and organ integrity during normal development and growth throughout the life process. Loss …

Protein folding is a substantively error prone process, especially when it occurs in the
endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory …

The ability to sense proteasome insufficiency and respond by directing the transcriptional
synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in …

To gain a better understanding of the multistep processing of Nrf1 to yield various isoforms
with confused molecular masses, we herein establish a generally acceptable criterion …

The membrane-bound transcription factor Nrf1 (encoded by Nfe2l1) is activated by sensing
glucose deprivation, cholesterol abundance, proteasomal inhibition and oxidative stress and …

Simple Summary As we age or develop certain brain diseases, our body's ability to maintain
a balanced protein system, termed “proteostasis”, is disturbed. Proteostasis is essential for …