Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Amelogenin and enamel biomimetics

Q Ruan, J Moradian-Oldak - Journal of Materials Chemistry B, 2015 - pubs.rsc.org
Mature tooth enamel is acellular and does not regenerate itself. Developing technologies
that rebuild tooth enamel and preserve tooth structure is therefore of great interest …

Intrinsically disordered proteins and biomineralization

AL Boskey, E Villarreal-Ramirez - Matrix Biology, 2016 - Elsevier
In vertebrates and invertebrates, biomineralization is controlled by the cell and the proteins
they produce. A large number of these proteins are intrinsically disordered, gaining some …

[HTML][HTML] The possible influence of genetic aetiological factors on molar–incisor hypomineralisation

L Hočevar, J Kovač, KT Podkrajšek, S Battelino… - Archives of oral …, 2020 - Elsevier
Objective The present study searched for evidence of possible associations between some
genetic factors that could affect the development of molar–incisor hypomineralisation (MIH) …

Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor

NY Shin, H Yamazaki, E Beniash, X Yang… - Journal of Biological …, 2020 - ASBMB
Dental enamel comprises interwoven arrays of extremely long and narrow crystals of
carbonated hydroxyapatite called enamel rods. Amelogenin (AMELX) is the predominant …

Secretome proteins regulate comparative osteogenic and adipogenic potential in bone marrow and dental stem cells

A Kumar, V Kumar, V Rattan, V Jha, S Bhattacharyya - Biochimie, 2018 - Elsevier
Introduction Dental stem cells (DMSC) have been studied extensively since their early
discovery. However, the data regarding osteogenic potential of DMSC with other cell types is …

Coemergence of the amphipathic helix on ameloblastin with mammalian prismatic enamel

J Su, RA Bapat, G Visakan… - Molecular Biology and …, 2022 - academic.oup.com
To investigate correlation between the ameloblastin (Ambn) amino acid sequence and the
emergence of prismatic enamel, a notable event in the evolution of ectodermal hard tissues …

Mapping the tooth enamel proteome and amelogenin phosphorylation onto mineralizing porcine tooth crowns

DR Green, F Schulte, KH Lee, MK Pugach… - Frontiers in …, 2019 - frontiersin.org
Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance,
composition and posttranslational modifications are critical to achieve healthy enamel …

Claudin‐16 deficiency impairs tight junction function in ameloblasts, leading to abnormal enamel formation

C Bardet, F Courson, Y Wu, M Khaddam… - Journal of Bone and …, 2016 - academic.oup.com
ABSTRACT Claudin‐16 protein (CLDN16) is a component of tight junctions (TJ) with a
restrictive distribution so far demonstrated mainly in the kidney. Here, we demonstrate the …

Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions

F Spoutil, G Aranaz-Novaliches, M Prochazkova… - Scientific Reports, 2023 - nature.com
Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in
odontogenic tissues and diverged from common ancestral gene. They are crucial for the …