Understanding the physical basis of memory: Molecular mechanisms of the engram

C Ortega-de San Luis, TJ Ryan - Journal of Biological Chemistry, 2022 - ASBMB
Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

RNA-binding proteins balance brain function in health and disease

R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Initial memory consolidation and the synaptic tagging and capture hypothesis

K Okuda, K Højgaard, L Privitera… - European Journal of …, 2021 - Wiley Online Library
Everyday memories are retained automatically in the hippocampus and then decay very
rapidly. Memory retention can be boosted when novel experiences occur shortly before or …

[HTML][HTML] miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's …

CJ Rodriguez‐Ortiz, GA Prieto, AC Martini, S Forner… - Aging cell, 2020 - ncbi.nlm.nih.gov
MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation of synaptic
functions. Among them, recent emerging evidence highlights that microRNA‐181a (miR …

A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions

ME Yurgel, P Kakad, M Zandawala, DR Nässel… - PLoS …, 2019 - journals.plos.org
Dysregulation of sleep and feeding has widespread health consequences. Despite
extensive epidemiological evidence for interactions between sleep and metabolic function …

Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling …

A Rezayof, Z Ghasemzadeh, OH Sahafi - Neurochemistry International, 2023 - Elsevier
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

From circuits to chromatin: the emerging role of epigenetics in mental health

P Mews, ES Calipari, J Day, MK Lobo… - Journal of …, 2021 - Soc Neuroscience
A central goal of neuroscience research is to understand how experiences modify brain
circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit …

Endoplasmic reticulum chaperone genes encode effectors of long-term memory

S Chatterjee, E Bahl, U Mukherjee, EN Walsh… - Science …, 2022 - science.org
The mechanisms underlying memory loss associated with Alzheimer's disease and related
dementias (ADRD) remain unclear, and no effective treatments exist. Fundamental studies …

Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional …

AA Keiser, TN Dong, EA Kramár, CW Butler… - Nature …, 2024 - nature.com
Exercise has beneficial effects on cognition throughout the lifespan. Here, we demonstrate
that specific exercise patterns transform insufficient, subthreshold training into long-term …

Neuroadaptations and TGF-β signaling: emerging role in models of neuropsychiatric disorders

S Mitra, C Werner, DM Dietz - Molecular psychiatry, 2022 - nature.com
Neuropsychiatric diseases are manifested by maladaptive behavioral plasticity. Despite the
greater understanding of the neuroplasticity underlying behavioral adaptations, pinpointing …