For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Groundwater contaminated with nitrate has prompted a flurry of research studies around the
world in the recent years to address this burning environmental issue. The common …

Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and
cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the …

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the
absence of sexual arousal. The current pharmacological treatments for SCD-associated …

Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged,
painful erections occurring without sexual arousal or desire. This urological emergency can …

Introduction: Priapism is prolonged penile erection in the absence of sexual arousal or
desire and is a devastating condition affecting millions of patients with sickle cell disease …

Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …

Sickle cell disease (SCD) is a genetic disorder that has been associated with priapism. The
role of hydroxyurea, a common SCD therapy, in influencing the nitric oxide (NO)-cGMP …

Sickle cell disease (SCD)‐associated priapism is characterized by decreased nitric oxide
(NO) signaling and downregulated phosphodiesterase (PDE) 5 protein expression and …

Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the
occlusion of small blood vessels by sickle-shaped red blood cells. SCD is associated with a …