Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

Last year brought a significant advance in asthma management, unyielding to the pressure
of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell …

Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

The development of monoclonal antibody therapies targeting specific components of the
pathways relevant to asthma pathophysiology has revolutionized treatment of severe …

The airway epithelium comprises of different cell types and acts as a physical barrier
preventing pathogens, including inhaled particles and microbes, from entering the lungs …

abstract Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding
to two types of receptors sharing the IL-4R a chain (IL-4Ra). Since IL-4 and IL-13 play …

Background Mucus plugs in asthmatic airways are associated with airway obstruction and
the activity of inflammatory cytokines, specifically interleukin (IL)-5 and IL-13, and they may …

Background Patients with eosinophilic asthma often report poor symptomatic control and
quality of life. Anti-IL-5 therapy, including anti-IL-5Rα (benralizumab), rapidly depletes …

Background Airway mucus plugs in asthma are associated with exacerbation frequency,
increased eosinophilia, and reduced lung function. The relationship between mucus plugs …

Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …