The helix-turn-helix (HTH) domain is a common denominator in basal and specific
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …

BACKGROUND Cellular life depends on the ability of organisms to accurately duplicate and
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …

In all organisms, multi-subunit replicases are responsible for the accurate duplication of
genetic material during cellular division. Initiator proteins control the onset of DNA …

Chromosomal replication must be limited to once and only once per cell cycle. This is
accomplished by multiple regulatory pathways that govern initiator proteins and replication …

The replication origin and the initiator protein DnaA are the main targets for regulation of
chromosome replication in bacteria. The origin bears multiple DnaA binding sites, while …

In bacteria, the initiation of replication is controlled by DnaA, a member of the ATPases
associated with various cellular activities (AAA+) protein superfamily. ATP binding allows …

The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

Bacteriophages (prokaryotic viruses) are favourite model systems to study DNA replication
in prokaryotes, and provide examples for every theoretically possible replication …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …