The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Abstract CD4+ CD25+ regulatory T lymphocytes (Tregs) are specialized T cells playing a
key role in the control of immune homeostasis. Here, we show that human Tregs …

Sympathoadrenergic pathways are crucial to the communication between the nervous
system and the immune system. The present review addresses emerging issues in the …

It is well established that catecholamines (CAs), which regulate immune and inflammatory
responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies …

Mast cells store an impressive array of preformed compounds (mediators) in their secretory
granules. When mast cells degranulate, these are released and have a profound impact on …

This study provides the first evidence for catecholamine synthesis and release in the
RAW264. 7 cell line, an important macrophage model. Although catecholamines were low in …

Hematopoiesis produce every day billions of blood cells and takes place in the bone marrow
(BM) by the proliferation and differentiation of hematopoietic stem cells (HSC). HSC are …