The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …

Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI
compartments contain specific microbiota, and microbiota dysbiosis is associated with …

Abstract N 6-methyladenosine (m6A), the most prevalent internal modification on eukaryotic
mRNA, plays an essential role in various stress responses. The brain is uniquely vulnerable …

Intestinal barrier dysfunction leads to inflammation and associated metabolic changes.
However, the relative impact of gut bacteria versus non-bacterial insults on animal health in …

Recent discoveries suggest that aging is neither driven by accumulation of molecular
damage of any cause, nor by random damage of any kind. Some predictions of a new …

As members of the mitogen-activated protein kinase (MAPK) family, the c-Jun N-terminal
kinases (JNKs) regulate cell responses to a wide range of extrinsic and intrinsic insults …

Uncovering the complexity of systems in non-model organisms is critical for understanding
arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …