Flavours of cheese products: metabolic pathways, analytical tools and identification of producing strains

L Marilley, MG Casey - International journal of food microbiology, 2004 - Elsevier
Aroma development in cheese products results from the metabolic activities of cheese
bacteria, by glycolysis, lipolysis and proteolysis. To respond to the increasing demand for …

Revisit of aminotransferase in the genomic era and its application to biocatalysis

BY Hwang, BK Cho, H Yun, K Koteshwar… - Journal of Molecular …, 2005 - Elsevier
Aminotransferases (ATs) have useful applications in the chemical industry because of their
capability of introducing amino group into ketones or keto acids as well as their high …

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

Z Zhu, A Achreja, N Meurs, O Animasahun, S Owen… - Nature …, 2020 - nature.com
Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic
cancers, and increased levels of BCAAs have been associated with increased risk of …

BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

QX Ma, WY Zhu, XC Lu, D Jiang, F Xu, JT Li… - Nature …, 2022 - nature.com
The link between branched-chain amino acids (BCAAs) and obesity has been known for
decades but the functional role of BCAA metabolism in white adipose tissue (WAT) of obese …

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

AE Papathanassiu, JH Ko, M Imprialou… - Nature …, 2017 - nature.com
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of
branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule …

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression

L Qian, N Li, XC Lu, M Xu, Y Liu, K Li, Y Zhang… - Nature …, 2023 - nature.com
Increased expression of branched-chain amino acid transaminase 1 or 2 (BCAT1 and
BCAT2) has been associated with aggressive phenotypes of different cancers. Here we …

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

MZ Lei, XX Li, Y Zhang, JT Li, F Zhang… - Signal transduction and …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with
most patients diagnosed at advanced stages. Increasing evidence indicates that elevated …

Functional impact of high protein intake on healthy elderly people

S Walrand, KR Short, ML Bigelow… - American Journal …, 2008 - journals.physiology.org
Decline in muscle mass, protein synthesis, and mitochondrial function occurs with age, and
amino acids are reported to enhance both muscle protein synthesis and mitochondrial …

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

JT Li, KY Li, Y Su, Y Shen, MZ Lei… - National Science …, 2022 - academic.oup.com
BCAT2-mediated branched-chain amino acid (BCAA) catabolism is critical for pancreatic
ductal adenocarcinoma (PDAC) development, especially at an early stage. However …

Discovery of NV-5138, the first selective Brain mTORC1 activator

S Sengupta, E Giaime, S Narayan, S Hahm, J Howell… - Scientific reports, 2019 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several
important chronic medical conditions many of which are associated with advancing age. A …