BY Hwang, BK Cho, H Yun, K Koteshwar… - Journal of Molecular …, 2005 - Elsevier
Aminotransferases (ATs) have useful applications in the chemical industry because of their capability of introducing amino group into ketones or keto acids as well as their high …
Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with increased risk of …
QX Ma, WY Zhu, XC Lu, D Jiang, F Xu, JT Li… - Nature …, 2022 - nature.com
The link between branched-chain amino acids (BCAAs) and obesity has been known for decades but the functional role of BCAA metabolism in white adipose tissue (WAT) of obese …
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule …
L Qian, N Li, XC Lu, M Xu, Y Liu, K Li, Y Zhang… - Nature …, 2023 - nature.com
Increased expression of branched-chain amino acid transaminase 1 or 2 (BCAT1 and BCAT2) has been associated with aggressive phenotypes of different cancers. Here we …
MZ Lei, XX Li, Y Zhang, JT Li, F Zhang… - Signal transduction and …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated …
S Walrand, KR Short, ML Bigelow… - American Journal …, 2008 - journals.physiology.org
Decline in muscle mass, protein synthesis, and mitochondrial function occurs with age, and amino acids are reported to enhance both muscle protein synthesis and mitochondrial …
JT Li, KY Li, Y Su, Y Shen, MZ Lei… - National Science …, 2022 - academic.oup.com
BCAT2-mediated branched-chain amino acid (BCAA) catabolism is critical for pancreatic ductal adenocarcinoma (PDAC) development, especially at an early stage. However …
S Sengupta, E Giaime, S Narayan, S Hahm, J Howell… - Scientific reports, 2019 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A …