Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control
of cortical and subcortical circuits and are thought to be a key locus of the pathophysiology …

The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Treatment of schizophrenia (SCZ) historically relies on the use of antipsychotic drugs to treat
psychosis, with all of the currently available antipsychotics acting through the antagonism of …

The alteration of excitatory–inhibitory (E–I) balance has been implicated in various
neurological and psychiatric diseases, including autism spectrum disorder (ASD). Fragile X …

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly and
constitutes the third highest risk factor for dementia. Lifetime noise exposure, genetic …

Impairments in gamma-aminobutyric acid (GABAergic) interneuron function lead to gamma
power abnormalities and are thought to underlie symptoms in people with schizophrenia …

Key points Gamma oscillations (30–80 Hz) are important for cognitive functions and depend
on the synchronized activity of fast‐spiking interneurons (FSN), which is crucial for network …

Fragile X syndrome (FXS) is characterized by hypersensitivity to sensory stimuli, including
environmental sounds. We compared the auditory brainstem response (ABR) recorded in …