Cancer metabolites: promising biomarkers for cancer liquid biopsy

W Wang, Z Rong, G Wang, Y Hou, F Yang, M Qiu - Biomarker Research, 2023 - Springer
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …

Multiplex protein imaging in tumour biology

N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Microlensed fiber allows subcellular imaging by laser-based mass spectrometry

Y Meng, W Hang, RN Zare - Nature Protocols, 2023 - nature.com
Mass spectrometry imaging (MSI) enables the chemical mapping of molecules and elements
in a label-free, high-throughput manner. Because this approach can be accomplished …

[HTML][HTML] Metabolomics in drug research and development: The recent advances in technologies and applications

H Pang, Z Hu - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Emerging evidence has demonstrated the vital role of metabolism in various diseases or
disorders. Metabolomics provides a comprehensive understanding of metabolism in …

Integrated analysis of metabolomics and lipidomics in plasma of T2DM patients with diabetic retinopathy

C Ding, N Wang, Z Wang, W Yue, B Li, J Zeng… - Pharmaceutics, 2022 - mdpi.com
Diabetic retinopathy (DR) is a major cause of blindness worldwide and may be non-
proliferative (NPDR) or proliferative (PDR). To investigate the metabolomic and lipidomic …

[HTML][HTML] METASPACE-ML: Context-specific metabolite annotation for imaging mass spectrometry using machine learning

B Wadie, L Stuart, CM Rath, B Drotleff… - Nature …, 2024 - nature.com
Imaging mass spectrometry is a powerful technology enabling spatial metabolomics, yet
metabolites can be assigned only to a fraction of the data generated. METASPACE-ML is a …

State-of-the-art mass spectrometry imaging applications in biomedical research

KK Krestensen, RMA Heeren, B Balluff - Analyst, 2023 - pubs.rsc.org
Mass spectrometry imaging has advanced from a niche technique to a widely applied spatial
biology tool operating at the forefront of numerous fields, most notably making a significant …

Advancing environmental toxicology: The role of mass spectrometry imaging

A Menéndez-Pedriza, L Molina-Millán… - Trends in Environmental …, 2024 - Elsevier
The growing global concern over pollution and its substantial effects on ecosystems and
human health has emphasized the critical need for a deeper chemical understanding of our …

Recent advances in mass spectrometry-based structural elucidation techniques

X Ma - Molecules, 2022 - mdpi.com
Mass spectrometry (MS) has become the central technique that is extensively used for the
analysis of molecular structures of unknown compounds in the gas phase. It manipulates the …

[HTML][HTML] Advanced progress of spatial metabolomics in head and neck cancer research

H Zhao, C Shi, W Han, G Luo, Y Huang, Y Fu, W Lu… - Neoplasia, 2024 - Elsevier
Head and neck cancer ranks as the sixth most prevalent malignancy, constituting 5% of all
cancer cases. Its inconspicuous onset often leads to advanced stage diagnoses, prompting …