Background Endometrial cancer (EC) is one of the worldwide gynecological malignancies.
Endoplasmic reticulum (ER) stress is the cellular homeostasis disturbance that participates …

Cervical cancer, the second most common female malignant tumor, seriously threatens
women's health and lives. Despite the availability of the HPV vaccine, effective treatment …

Open chromatin regions are the genomic regions associated with basic cellular
physiological activities, while chromatin accessibility is reported to affect gene expressions …

In cancer genomics, variant calling has advanced, but traditional mean accuracy evaluations
are inadequate for biomarkers like tumor mutation burden, which vary significantly across …

Introduction T cell receptor (TCR) repertoires provide valuable insights into complex human
diseases, including cancers. Recent advancements in immune sequencing technology have …

Background Studies have revealed that acute myeloid leukemia (AML) patients are prone to
combined cardiac injury. We aimed to identify hematological risk factors associated with …

Background Accurate microsatellite instability (MSI) testing is essential for identifying gastric
cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT …

Background ATP7B is a copper-transporting protein that contributes to the chemo-resistance
of human cancer cells. It remains unclear what the molecular mechanisms behind ATP7B …

Background Increasing evidence suggests that the metabolism of lipids plays a crucial role
in the progression of gastric cancer. However, the expression of lipid metabolism-related …

Tumor Mutation Burden (TMB) serves as a recognized stratified biomarker for
immunotherapy. However, its one-dimensional representation of non-synonymous genetic …