Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-
specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions …

Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly
quiescent, and only a few are in cell cycle at any point in time. DG NSCs become …

Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow
saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple …

Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ)
contribute to brain repair during CNS disease. The microenvironment within the SVZ stem …

Eukaryotic gene expression is heavily regulated at the transcriptional and post-
transcriptional levels. An additional layer of regulation occurs co-transcriptionally through …

The adult brain, even though largely postmitotic, is now known to have dividing cells that can
make both glia and neurons. Of these, the precursor cells that have the potential to make …