Alternative strategies in arrhythmia therapy: evaluation of Na/Ca exchange as an anti-arrhythmic target

G Antoons, R Willems, KR Sipido - Pharmacology & therapeutics, 2012 - Elsevier
The search for alternative anti-arrhythmic strategies is fueled by an unmet medical need as
well as by the opportunities arising from identification of novel targets and novel drugs …

Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond

G Katz, M Arad, M Eldar - Current problems in cardiology, 2009 - Elsevier
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a primary electrical
myocardial disease characterized by exercise-and stress-related ventricular tachycardia …

The role of the Na+/Ca2+ exchanger, INa and ICaL in the genesis of dofetilide‐induced torsades de pointes in isolated, AV‐blocked rabbit hearts

AS Farkas, P Makra, N Csík, S Orosz… - British journal of …, 2009 - Wiley Online Library
Background and purpose: The Na+/Ca2+ exchanger (NCX) may contribute to triggered
activity and transmural dispersion of repolarization, which are substrates of torsades de …

Disruption of Atrial Rhythmicity by the Air Pollutant 1, 2-Naphthoquinone: Role of Beta-Adrenergic and Sensory Receptors

AG Soares, SA Teixeira, P Thakore, LG Santos… - Biomolecules, 2023 - mdpi.com
The combustion of fossil fuels contributes to air pollution (AP), which was linked to about
8.79 million global deaths in 2018, mainly due to respiratory and cardiovascular-related …

The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice

H Ma, J Zhou, J Jiang, J Duan, H Xu, Y Tang… - Experimental and …, 2012 - Elsevier
Toad Venom, called chansu (CS) in China, is an anti-inflammatory drug used in small doses
for the treatment of various types of inflammation in China. Its use is hampered by the …

[PDF][PDF] Effects of acute administration of ethanol on experimental arrhythmia

Y Gao, P Li, LX Ma, KX Du, XH Wang, MJ Tang, HK He… - Chin J Physiol, 2012 - cps.org.tw
Many studies have shown that the relationship between alcohol consumption and most
cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher …

Effects of SEA0400 on Arrhythmogenicity in a Langendorff‐Perfused 1‐Month Myocardial Infarction Rabbit Model

CC CHOU, POC CHANG, MS WEN… - Pacing and Clinical …, 2013 - Wiley Online Library
Background The effects of SEA0400, a Na+/Ca2+ exchanger (NCX) blocker, on dynamic
factors and arrhythmogenic alternans in 1‐month myocardial infarction (MI) hearts remain …

[HTML][HTML] Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model

PC Chang, HT Wo, HL Lee, MS Wen, CC Chou - Journal of cardiology, 2015 - Elsevier
Abstract Background Na+/Ca 2+ exchanger blockade has been reported to be anti-
arrhythmic in different models. The effects of KB-R7943, a Na+/Ca 2+ exchanger blocker, on …

Direct loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 …

L Boyman, R Hiller, WJ Lederer, D Khananshvili - Biochemistry, 2008 - ACS Publications
The Na+− Ca2+ exchanger in mammalian heart muscle (NCX1) is the central transporter
protein that regulates extrusion of Ca2+ from the heart cell. However, the functional …

[PDF][PDF] Натрий-зависимое поглощение ионов кальция в изолированном сердце крысы при гипоксии и ишемии и связь этого процесса с возникновением …

ВВ Алабовский, АА Винокуров… - … . Серия: Химия. Биология …, 2009 - vestnik.vsu.ru
Наиболее опасным для жизни последствием острого инфаркта миокарда является
возникновение фибрилляции желудочков сердца. Причины быстрого нарушения …