To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …

Neuronal conversion from human fibroblasts can be induced by lineage-specific
transcription factors; however, the introduction of ectopic genes limits the therapeutic …

Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can
selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively …

DREADDs are chemogenetic tools widely used to remotely control cellular signaling,
neuronal activity, and behavior. Here we used a structure-based approach to develop a new …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Recent studies have shown evidence of behavioral recovery after transplantation of human
pluripotent stem cell (PSC)-derived neural cells in animal models of neurological disease …

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an
increasingly popular approach for “remotely controlling” selected neuronal populations and …

Summary Transplantation of GABAergic interneurons (INs) can provide long-term functional
benefits in animal models of epilepsy and other neurological disorders. Whereas GABAergic …

Transplantation of human pluripotent stem cell (hPSC)-derived neurons is a promising
avenue for treating disorders including Parkinson's disease (PD). Precise control over …