Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum

R Guerrini, V Conti, M Mantegazza… - Physiological …, 2023 - journals.physiology.org
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development

JL Green, WF Dos Santos, ACK Fontana - Biochemical pharmacology, 2021 - Elsevier
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

[HTML][HTML] The solute carrier transporters and the brain: Physiological and pharmacological implications

C Hu, L Tao, X Cao, L Chen - Asian journal of pharmaceutical sciences, 2020 - Elsevier
Solute carriers (SLCs) are the largest family of transmembrane transporters that determine
the exchange of various substances, including nutrients, ions, metabolites, and drugs across …

Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

M Zheng, H Ye, X Yang, L Shen, X Dang, X Liu… - Brain, Behavior, and …, 2024 - Elsevier
Obesity is a risk factor for cognitive dysfunction and neurodegenerative disease, including
Alzheimer's disease (AD). The gut microbiota-brain axis is altered in obesity and linked to …

[HTML][HTML] Functional and biochemical consequences of disease variants in neurotransmitter transporters: a special emphasis on folding and trafficking deficits

S Bhat, A El-Kasaby, M Freissmuth, S Sucic - Pharmacology & therapeutics, 2021 - Elsevier
Neurotransmitters, such as γ-aminobutyric acid, glutamate, acetyl choline, glycine and the
monoamines, facilitate the crosstalk within the central nervous system. The designated …

Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury

W Luo, Z Yang, J Zheng, Z Cai, X Li, J Liu, X Guo… - ACS …, 2024 - ACS Publications
Self-assembly of hydrogels for mechanical support and drug delivery has been extensively
researched in traumatic brain injury (TBI), where treatment options are limited. The chief …

A 2020 view on the genetics of developmental and epileptic encephalopathies

HC Happ, GL Carvill - Epilepsy currents, 2020 - journals.sagepub.com
Developmental and epileptic encephalopathies (DEEs) can be primarily attributed to genetic
causes. The genetic landscape of DEEs has been largely shaped by the rise of high …

Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity

AL Hotz, A Jamali, NN Rieser, S Niklaus, E Aydin… - Glia, 2022 - Wiley Online Library
Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

Structural aspects of photopharmacology: insight into the binding of photoswitchable and photocaged inhibitors to the glutamate transporter homologue

V Arkhipova, H Fu, MWH Hoorens… - Journal of the …, 2021 - ACS Publications
Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …

Amino acid transport defects in human inherited metabolic disorders

R Yahyaoui, J Pérez-Frías - International journal of molecular sciences, 2019 - mdpi.com
Amino acid transporters play very important roles in nutrient uptake, neurotransmitter
recycling, protein synthesis, gene expression, cell redox balance, cell signaling, and …