Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment

X Chen, Y Feng, RJ Quinn, DL Pountney… - Pharmacological …, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

Snake venom peptides: Tools of biodiscovery

A Munawar, SA Ali, A Akrem, C Betzel - Toxins, 2018 - mdpi.com
Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …

Kv1. 3 channel as a key therapeutic target for neuroinflammatory diseases: state of the art and beyond

X Wang, G Li, J Guo, Z Zhang, S Zhang, Y Zhu… - Frontiers in …, 2020 - frontiersin.org
It remains a challenge for the effective treatment of neuroinflammatory disease, including
multiple sclerosis (MS), stroke, epilepsy, and Alzheimer's and Parkinson's disease. The …

Minor snake venom proteins: Structure, function and potential applications

J Boldrini-França, CT Cologna, MB Pucca… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Snake venoms present a great diversity of pharmacologically active compounds that may be
applied as research and biotechnological tools, as well as in drug development and …

Treating autoimmune disorders with venom-derived peptides

B Shen, Z Cao, W Li, JM Sabatier… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The effective treatment of autoimmune diseases remains a challenge. Voltage-
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …

Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms

MRA Rusmili, TT Yee, MR Mustafa, WC Hodgson… - Journal of …, 2014 - Elsevier
Kraits (Bungarus spp.) are highly venomous elapids that are only found in Asia. In the
current study, 103 and 86 different proteins were identified from Bungarus candidus and …

Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King …

S Kunalan, I Othman, S Syed Hassan, WC Hodgson - Toxins, 2018 - mdpi.com
Calloselasma rhodostoma (CR) and Ophiophagus hannah (OH) are two medically important
snakes found in Malaysia. While some studies have described the biological properties of …

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

Y Zhao, J Huang, X Yuan, B Peng, W Liu, S Han, X He - Toxins, 2015 - mdpi.com
Autoimmune diseases are usually accompanied by tissue injury caused by autoantigen-
specific T-cells. KV1. 3 channels participate in modulating calcium signaling to induce T-cell …

[HTML][HTML] Characterization of Kunitz-Domain Anticoagulation Peptides Derived from Acinetobacter baumannii Exotoxin Protein F6W77

F Sun, X Deng, H Gao, L Ding, W Zhu, H Luo, X Ye… - Toxins, 2024 - mdpi.com
Recent studies have revealed that the coagulation system plays a role in mammalian innate
defense by entrapping bacteria in clots and generating antibacterial peptides. So, it is very …

Study of the venom proteome of Vipera ammodytes ammodytes (Linnaeus, 1758): A qualitative overview, biochemical and biological profiling

K Gopcevic, I Karadzic, L Izrael-Zivkovic… - … and Physiology Part D …, 2021 - Elsevier
Vipera ammodytes (Va), is the European venomous snake of the greatest medical
importance. We analyzed whole venom proteome of the subspecies V. ammodytes …