In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

The murine homeo box gene Nkx2-5 is expressed in precardiac mesoderm and in the
myocardium of embryonic and fetal hearts. Targeted interruption of Nkx2-5 resulted in …

We have isolated two murine homeobox genes, Nkx-2. 5 and Nkx-2. 6, that are new
members of a sp sub-family of homeobox genes related to Drosophila NK2, NK3 and …

The homeobox-containing gene tinman (msh-2, Development 110, 661-669) is expressed in
the mesoderm primordium, and this expression requires the function of the mesoderm …

twist and snail are members of the helix-loop-helix and zinc-finger protein families,
respectively, and determine the development of the mesoderm in Drosophila. This paper …

ABSTRACT Csx/Nkx2. 5 is a vertebrate homeobox gene with a sequence homology to the
Drosophila tinman, which is required for the dorsal mesoderm specification. Recently …

The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two
early markers of precardiac cells. Both are essential for heart formation, but neither can …

Little is known about the molecular mechanisms that govern heart specification in
vertebrates. Here we demonstrate that bone morphogenetic protein (BMP) signaling plays a …

Forward-genetic analyses in Drosophila and Caenorhabditis elegans have given us
unprecedented insights into many developmental mechanisms. To study the formation of …