Though the vascular system of the adult brain is extremely stable under normal baseline
conditions, endothelial cells start to proliferate in response to brain ischemia. The induction …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …

Angiogenesis plays an important role in the remodeling process of the ischemic brain and
the recovery of neurological function after ischemic stroke. Ginsenoside Rg1 has been …

One of the exciting advances in modern medicine and life science is cell-based
neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The …

Cell therapy is emerging as a viable therapy to restore neurological function after stroke.
Many types of stem/progenitor cells from different sources have been explored for their …

Stem cell transplantation therapy has emerged as a promising regenerative medicine for
ischemic stroke and other neurodegenerative disorders. However, many issues and …

Hypoxic preconditioning (HP) and stem cell transplantation have been extensively studied
as individual therapies for ischemic stroke. The present investigation is an initial effort to …

Ischemic stroke is a disease with high morbidity and mortality worldwide, which often places
an additional strain on families and society due to the poor prognosis. Blood brain-barrier …

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood
cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor …

Protective strategies against perinatal brain injury represent a major challenge for modern
neonatology. Erythropoietin (Epo) enhances endogenous mechanisms of repair and …