Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including
activation of many inflammatory processes (through activation of T cells, for example) …

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the
molecular mechanisms rendering the aged brain particularly susceptible to …

Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's
disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the …

Alzheimer disease is the most common cause of dementia and represents a major public
health problem. The neuropathologic findings of amyloid-β plaques and tau containing …

Transgenic mice overexpressing the P301L mutant human tau protein exhibit an
accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The …

Loss-of-function mutations of the parkin gene are a major cause of early-onset
parkinsonism. To explore the mechanism by which loss of parkin function results in …

An increasing number of publications are replicating a previously reported disease-marker
association but with the risk allele reversed from the previous report. Do such" flip-flop" …

Importance BecauseAPOElocus variants contribute to risk of late-onset Alzheimer disease
(LOAD) and to differences in age at onset (AAO), it is important to know whether other …