During the past 5 years there has been an increasing body of literature describing the roles
cardiac myosin binding protein C (cMyBP-C) phosphorylation play in regulating cardiac …

In the 20 years since the discovery of the first mutation linked to familial hypertrophic
cardiomyopathy (HCM), an astonishing number of mutations affecting numerous sarcomeric …

Background—Heart failure with preserved left ventricular (LV) ejection fraction (EF) is
increasingly recognized and usually referred to as diastolic heart failure (DHF). Its …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Cardiac myosin–binding protein-C (cMyBP-C) is a thick filament-associated protein that
seems to contribute to the regulation of cardiac contraction through interactions with either …

Cardiac myosin-binding protein C (cMyBP-C) is a regulatory protein expressed in cardiac
sarcomeres that is known to interact with myosin, titin, and actin. cMyBP-C modulates …

Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments
and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C …

Normal cardiac function requires dynamic modulation of contraction. β1-Adrenergic–
induced protein kinase (PK) A phosphorylation of cardiac myosin binding protein (cMyBP)-C …

We sought to establish a large animal model of inherited hypertrophic cardiomyopathy
(HCM) with sufficient disease severity and early penetrance for identification of novel …

or myocyte alkalization. This type of change would primarily manifest in normal operating
ranges of Ca2 activation. A potential problem is that force generation is also greater at …