Properdin, the widely known positive regulator of the alternative pathway (AP), has
undergone significant investigation over the last decade to define its function in inflammation …

SUmmARY of the general population with community-acquired bacterial meningitis, but
reported a longer prodromal phase. According to literature data, the prevalence of the …

Properdin is known as the only positive regulator of the complement system. Properdin
promotes the activity of this defense system by stabilizing its key enzymatic complexes: the …

Sepsis is a leading cause of death in the United States and worldwide. Early recognition and
effective management are essential for improved outcome. However, early recognition is …

The complement system alternative pathway (AP) can be activated excessively in
inflammatory diseases, particularly when there is defective complement regulation. For …

Complement factor properdin (CFP), encodes plasma glycoprotein, is a critical gene that
regulates the complement pathway of the innate immune system. However, correlations of …

Domingo and colleagues, in this Journal, reported the increased incidence of Listeria
meningitis in elderly amongst more recent cohorts. 1 In ageing people, infections are not …

The complement system consists of three pathways (alternative, classical, and lectin) that
play a fundamental role in immunity and homeostasis. The multifunctional role of the …

Citrobacter rodentium is an attaching and effacing mouse pathogen that models
enteropathogenic and enterohemorrhagic Escherichia coli in humans. The complement …

Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in
humans and mice. Complement activation is an integral part of the innate immune defence …