In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …
E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
Comparison of minipig, dog, monkey and human drug metabolism and disposition
L Dalgaard - Journal of pharmacological and toxicological methods, 2015 - Elsevier
Introduction This article gives an overview of the drug metabolism and disposition (ADME)
characteristics of the most common non-rodent species used in toxicity testing of drugs …
characteristics of the most common non-rodent species used in toxicity testing of drugs …
A model-based approach to assessing the importance of intracellular binding sites in doxorubicin disposition
Doxorubicin is an anticancer agent, which binds reversibly to topoisomerase I and II,
intercalates to DNA base pairs, and generates free radicals. Doxorubicin has a high tissue …
intercalates to DNA base pairs, and generates free radicals. Doxorubicin has a high tissue …
Transcriptome profiling of placenta through pregnancy reveals dysregulation of bile acids transport and detoxification function
Placenta performs the function of several adult organs for the fetus during intrauterine life.
Because of the dramatic physiological and metabolic changes during pregnancy and the …
Because of the dramatic physiological and metabolic changes during pregnancy and the …
Conjugated estrogens in the endometrium during the estrous cycle in pigs
AK Hankele, S Bauersachs, SE Ulbrich - Reproductive biology, 2018 - Elsevier
Estrogen metabolism results in the formation of inactive estrogen sulphates and
glucuronides. Despite the lack of receptor binding, circulating conjugated estrogens might …
glucuronides. Despite the lack of receptor binding, circulating conjugated estrogens might …
Interaction of swine organic anion transporting polypeptide 1a2 with tetracycline, macrolide and β-lactam antibiotics
X Lin, Z Xiang, B Wang, H Chen, T Zhou… - Toxicology and Applied …, 2019 - Elsevier
Organic anion-transporting polypeptides (human OATPs; animals Oatps; gene symbol
SLCO/Slco) are integral membrane proteins that mediate the sodium-independent transport …
SLCO/Slco) are integral membrane proteins that mediate the sodium-independent transport …
Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs
E Sjögren, M Hedeland, U Bondesson… - European Journal of …, 2014 - Elsevier
The pharmacokinetics (PK) of fexofenadine (FEX) in pigs were investigated with the focus on
exploring the interplay between hepatic transport and metabolism when administered …
exploring the interplay between hepatic transport and metabolism when administered …
Characterization of the membrane transporter OATP1A2 activity towards different classes of drugs
J Lu - 2017 - papyrus.bib.umontreal.ca
Drug transporters are important determinants in drug disposition, efficacy, and toxicity. They
influence the pharmacokinetics and pharmacodynamics of drugs. Several clinically …
influence the pharmacokinetics and pharmacodynamics of drugs. Several clinically …