Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Background: Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water
bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by …

Abstract Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer
progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess …

The effects of estrogen are widespread throughout the body. Although the classical nuclear
estrogen receptors have been known for many years to decades and their primary modes of …

Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular
events are involved in controlling malignant cell processes. In this sense, there is an …

The steroid hormone oestrogen can signal through several receptors and pathways.
Although the transcriptional responses mediated by the nuclear oestrogen receptors (ER) …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …