Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a
degenerative disease that selectively affects upper and lower motor neurons and is fatal 3–5 …

To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …

Amyotrophic lateral sclerosis (ALS) is a paralytic and usually fatal disorder caused by motor-
neuron degeneration in the brain and spinal cord. Most cases of ALS are sporadic but about …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the
transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy …

High levels of familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 mutants G93A and
G37R were previously shown to mediate disease in mice through an acquired toxic property …

Analysis of transgenic mice expressing familial amyotrophic lateral sclerosis (ALS)–linked
mutations in the enzyme superoxide dismutase (SOD1) have shown that motor neuron …

The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …