Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …

Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

The xenoestrogen bisphenol-A (BPA) is a widespread environmental contaminant that has
been studied for its impact on male fertility in several species of animals and humans …

Various proapoptotic stimuli increase the production of superoxide and H 2 O 2 by
mitochondria. Whereas superoxide impairs mitochondrial function and is removed by Mn 2+ …

H 2 O 2 is a reactive oxygen species that has drawn much interest because of its role as a
second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have …